Proton Pump Inhibitors

Proton pump inhibitors (PPI) are widely and generously prescribed to treat acid reflux, heartburn, ulcers, and to prevent these and similar conditions. Long-term PPI use can cause osteoporosis, bone fractures, seizures and fatal heart arrhythmias. Short-term use can lead to serious infections and PPI dependency.

Proton Pump Inhibitor Dangers

PPIs are meant for short-term use, typically four to eight weeks. Long-term use increases the risk of very serious and sometimes fatal side effects. Short-term use can also lead to dangerous side effects and rebound acid causing dependency forcing the patient to enter long-term use of these dangerous drugs.

PPI injuries can include:

  • Osteoporosis
  • Hip fracture
  • Spine fracture
  • Wrist fracture
  • Magnesium deficiency
  • B12 deficiency
  • Seizures
  • Heart arrhythmias
  • Food poisoning
  • Clostridium difficile–associated diarrhea (CDAD)
  • Pneumonia
  • Rebound acid
  • PPI dependency

Proton Pump Inhibitor Types and Brands

Prescription proton pump inhibitors include:

  • Nexium (esomeprazole magnesium)
  • Prilosec (omeprazole)
  • Prevacid (lansoprazole)
  • AcipHex (rabeprazole sodium)
  • Dexilant (dexlansoprazole)
  • Protonix (pantoprazole sodium)
  • Vimovo (esomeprazole magnesium and naproxen)
  • Zegerid (omeprazole and Sodium bicarbonate)

Over-the-counter (OTC) brands include:

  • Prevacid 24HR (lansoprazole)
  • Prilosec OTC (omeprazole magnesium)
  • Zegerid OTC (omeprazole and sodium bicarbonate)
  • Omeprazole (omeprazole)

Proton Pump Inhibitor Uses

PPI’s reduce the production of stomach acid. They are used to treat:

  • Gastroesophageal reflux disease (GERD)
  • Peptic ulcer disease (PUD)
  • Laryngopharyngeal reflux
  • Dyspepsia
  • Barrett’s esophagus
  • Gastrinomas
  • Zollinger-Ellison syndrome

PPI’s are also used to prevent stress gastritis.

Malabsorption Leading to Fractures, Heart Arrhythmias, and Other Injuries

Stomach acid is necessary for proper digestion and absorption of nutrients. PPI’s are the most potent acid suppressing drugs available. The long term side effects of PPI use are the result vitamin and mineral deficiencies due to malabsorption.

Osteoporosis, bone fractures, heart arrhythmias, and seizures are among the side effects of PPI caused magnesium deficiency due to malabsorption. Magnesium deficiency can be fatal.


Reduced acid allows bacteria to colonize in the gastrointestinal tract. This can obviously lead to infections in the gastrointestinal tract, and the bacteria can move to other parts of the body causing other types of infection including community-acquired pneumonia.

Clostridium difficile–associated diarrhea (CDAD) is a dangerous type of diarrhea which does not improve and can become life-threatening. It is caused by a bacterium called clostridium difficile (C. difficile).

Stomach acid is also a natural defense against food-borne illness. People who take PPI are more likely to get food poisoning than people with adequate stomach acid, when exposed to contaminated food.

If you have experienced any of these proton pump inhibitor injuries or lost a loved one to one of these dangerous, and overprescribed, drugs, please find a proton pump inhibitor injury lawyer in your area today.